About the Job
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.
One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. And driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.
Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.
The Protein Science group in Molecular Discovery Technologies provides protein production, analytical, and biophysical characterization of protein targets, protein reagents, as well as therapeutic and reagent antibodies. This group supports programs across all BMS therapeutic areas including Immuno-oncology (IO), Oncology, Immunoscience, and Fibrosis, and all modalities including biologics, small molecules and cycle peptides.
This position will be responsible for providing biophysical characterization support for protein therapeutic candidates and protein reagents including molecular interactions using biosensors and various bioanalytical techniques for analytical and stability assessment. The successful candidate will serve as a protein chemistry leader within the Molecular Discovery Technologies organization, as well as interface with other functional organizations and project teams across Discovery and early Development.
Responsibilities include but are not limited to\:
- Develop BIAcore SPR and other biosensor-based binding assays for characterization of protein interactions
- Determining the molecular mode of action of therapeutic candidate molecules using biosensor technologies (e.g., confirm binding, measure affinity/kinetics, distinguish binding epitopes, evaluate relationship to target oligomerization, discover novel binding modes).
- Conduct analytical characterization experiments for therapeutic candidate, reagent and tool molecules using analytical chromatography, iCIEF, mass spectrometry or other analytical assays
- Characterize protein structure, stability, and aggregation state, using technologies such as microcalorimetry, spectroscopy, light scattering, solubility assays, etc.
- Conduct biophysical characterization, stability and developability assessment of therapeutic candidate biologics in support of lead selection
- Provide protein chemistry leadership to project teams and drug discovery working groups across multiple therapeutic areas
- Communicate results written and verbally to multi-disciplinary team members.Qualification:
- Ph.D. in Biochemistry, Biophysics, Analytical Chemistry or related field with 2-4 years of post-doctoral work experience; preferably including experience in a Biotech, Pharma or Biopharma setting.
- Experience with quantitative analysis of protein-protein interactions using BIAcore surface plasmon resonance (SPR) or related biosensor techniques, including kinetics and affinity, mechanism of action is a requirement
- Some experience with protein analytical characterization techniques such as analytical size exclusion chromatography (SEC), imaged capillary isoelectric focusing (iCIEF), liquid chromatography mass spectrometry (LC-MS), is preferred
- Experience with biophysical characterization of proteins such as oligomeric structure and stability using microcalorimetry, fluorescence or other spectroscopy, light scattering or other related technologies would also be an advantage
- Knowledge of antibody engineering, structure, and interactions including binding to Fc receptors would be desired
- Excellent communication skills, evidence of innovative thinking, and ability/potential to function at a high level in a matrixed environment
- Additional skills/experience that would be advantageous\: protein purification, familiarity with automation, electronic lab notebook or LIMS systems, bioinformatics