Oncology Translational Medicine Lead

Bristol-Myers Squibb Princeton, NJ

About the Job


Oncology Translational Medicine Team Lead (TMTL) - D08   Bristol-Myers Squibb is actively conducting translational medicine research to further our understanding of cancer biology and to identify which patient populations may be more likely to derive benefit from Immuno-Oncology (I-O) and other therapies.  Bristol-Myers Squibb has long believed the future of cancer research is dependent on investments in science and partnerships. Collaboration is integrated into our organizational framework across translational medicine and R&D.    We are seeking a candidate who brings deep scientific experience with an emphasis on biomarkers, in depth knowledge of the oncology disease area, a clinical development perspective, and matrix management expertise to the role. This role will report to the Head of Precision Medicine within the Translational Medicine Division of R&D.   Role Responsibilities Represents and accountable for all TM functions (including Biomarkers, Pharmacodiagnostics (PDx), Translational Sciences, Integrated Sciences, Enabling Solutions, Bioinformatics and Translational Biology) in establishing the TM asset strategy Responsible for the translational medicine strategy as a core member of Early and/or late Asset Development Teams (EADT/DTs). Facilitates necessary governance reviews for strategy endorsement. Responsible for developing and implementing TM aspects of clinical development plans. Partners with Clinical, Biostatistics, Regulatory, Discovery, Clinical Operations, Project Management and other development team members to develop and implement scientific strategies for biomarker and diagnostic development. Partners with Medical Affairs and Commercial to develop Medical and Communication strategies. Participates in strategic overview of presentations, publications and internal/external communications along with accountable Translational Medicine Leadership. Manages and integrates Translational Medicine issues for resolution among the broad Translational Medicine matrixed team subject matter experts Accountable to ensure well-crafted and focused biomarker and patient selection hypotheses, experimental design, execution, interpretation and delivery of biomarker data   seamlessly integrated with clinical data Provides leadership to prioritize biomarkers for pull through to PDx, and seamless efficient transition to PDx development and commercialization Accountable for all EADT/DT PDx deliverables including co-development and regulatory submissions in partnership with diagnostic companies. Accountable for ensuring appropriate and focused resourcing requests are made with appropriate discipline In partnership with Medical Affairs, provides input and maintains an overview of all ISRs related to assigned EADT/DT(s) Accountable for the scientific input and review into all biomarker aspects of protocols aligned with EADT/DT objectives while ensuring alignment with TM Leadership Team and other key stakeholders Accountable for the scientific input and review into all biomarker aspects of clinical study reports, regulatory documentation and regulatory responses. Ensures that TM team is focused on key issues and that individual asset strategies and plans are integrated with broader TM strategy (across assigned EADT/DTs) Contributes to due diligence efforts relating to technologies, asset acquisition/licensing etc.



  • MD or PhD, or equivalent advanced biology degreeExperienced scientist with 12+ years’ experience in the drug discovery and development process.

  • Documented experience in oncology drug development (small molecule and biologic / immuno-oncology) in one or more major disease areas (e.g. melanoma, lung cancer, hematologic cancers, lymphoma, etc.)

  • Deep understanding of the role of translational research/medicine and clinical biomarkers in drug development.  Pharmocodiagnostics experience highly desired but not required.

  • The successful candidate will be a highly motivated, confident, and collaborative scientist with the ability to manage multiple projects simultaneously and show the ability to prioritize.

  • Demonstrated ability of working effectively to influence stakeholders in a highly dynamic matrix organization such as BMS.

  • Comfortable working in a fast-paced environment where speed is paramount

  • Willing to work as a topic expert, outside of a traditional functional environment, in a team unified around serving the assets

  • Ability to recognize, articulate, and accept calculated risks to make informed decisions

  • Demonstrated experience in the appropriate application of various scientific technologies into translational research strategies

  • Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc.

  • Demonstrated scientific acumen and mechanistic understanding of disease biology.

  • Proven leadership experience and success with leading teams. Act as an inclusive leader.

  • Operates with independence, and possesses the confidence and fortitude to take principled positions.

  • Ability to work effectively in a matrix environment that includes interactions with multiple stakeholder groups; particularly demonstrated ability to work across the critical interfaces whether within RD or across the enterprise.

  • Excellent communication and presentation skills, high level negotiation skills and the ability to resolve conflict in a constructive manner.